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    I have two cats; a sixteen year old tortoiseshell named Taddy, and a very big, and very fat - nearly nine kilos – cuddly ginger, named Shadow.

    Recently, Shadow disappeared for three days. Both my husband and I went out day and night looking for him, to no avail.

    Now, it needs to be said that Shadow is not the kind of cat who just disappears. No,
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    this is a cat who loves his food and comes running with the slighted hint of food appearing. I had visions of him either being hit by a car or some unscrupulous person ‘catnapping’ him. (Why anyone would want a foodaholic cat I’ll never know!)

    After three days of checking animal shelters and searching the streets, and still no Shadow, I decided
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    to door-knock the neighbours. The third house I called at had heard ‘ghostly’ meows at all hours, and a ‘ghost cat’ walking the house. Hmmm, that sounded like my Shadow.

    After four hours of trying to pinpoint exactly where in the neighbour’s house he was, the husband neighbour remembered that the day Shadow disappeared, their roof had been repair
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    d. I went home to get my son and my hubby’s ladder (heights are not my forte) only to get back out on the street to find my neighbour waiting. “We’ve found your cat,” he told me. “He’s looking down at us from the manhole.”

    Yes, he was, but it took twenty minutes to coax him down, poor darling. And he’s been following me around, and making up for
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    his loss of food ever since. (Incidentally, we called him Shadow because he follows me everywhere.)

    Why, you ask, is this crazy woman telling me about her cat?

    Whether it be fiction or non-fiction (or both), as writers, we need to be forever on the lookout for ideas. This used to be a major drawback for me. Not so these days. Learning to find id
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    as does not necessarily come naturally – it’s something that, with practice, will get easier with habit.

    The story about my fat fluffy cat, Shadow, will eventually become either a short story, an essay, or maybe even a non-fiction article - perhaps all three. Let’s look at turning it into a non-fiction article. First of all, ask yourself if there
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    is a need for such an article. To decide this, answer a few questions: How many other people have lost their beloved pets in this fashion? How many have given up hope (as I nearly did), and how many had no idea where to start? Assuming, as I have, that there is a need for the information, and therefore, an article, you would then need to work ou
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    the sort of content you would want to use. Think of some questions that need to be addressed. I find brainstorming is the best technique to work out my content. In this instance (for this particular subject) I could ask:

    When a pet goes missing, where should you start looking? How long is average for a pet to be found? Can animal shelters help?
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    Is it beneficial to have your pet micro-chipped? Will animal shelters contact you if your pet is micro-chipped or wears a tag? Is this definite? Is it better to check in person or can you rely on the shelter contacting you? What is the procedure used by shelters and pounds? How does an animal catcher/ranger determine if a pet is a stray? Quotes fr
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    m animal catcher/ranger/council/shire regarding missing pets. Facts and figures (statistics)?

    The above list took me just a few minutes to develop, but as you can see, I have the basis for an article. And so, with some research, photos and planting bottom firmly on seat, I have my non-fiction article. With a little extra work, I could re-write an
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    d sell the article to more than one market, generating additional income. (It is much easier to sell articles that come complete with photographs, so give this some serious consideration.)

    Anthologies are a major business these days, and their editors are constantly looking for content. No matter which publication, ezine or website, the majority
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    carry market information. More often than not, there will be at least one listing at any given time, for anthology submissions that are required. Some of these may not suit your current needs, but some, such as the Chicken Soup series, A Cup of Comfort series etc, have ongoing needs for stories. Some have a newsletter to which you can subscribe fo
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    notification of current requirements. For others, you will just have to keep an eye open.

    At some point in time, maybe not right away, possibly in the future, there will be an anthology or a collection of short stories, or even a magazine that will require Shadow’s story to be relayed in one form or another.

    Perhaps I should look further back i
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    nto my past for material? Around fifteen years ago - when my children were very young, my son ‘hid’ from his terrified parents after running away on a bush walk. He was missing for nearly two hours and we were on the verge of calling the police when the little darling jumped out of a bush and said, “Ha ha, I tricked you!” No, we’ve never let him f
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    rget it.

    There was also the time when our family were on holidays, working our way up the coast of Australia, from Melbourne to the Gold Coast. We stopped at Port Macquarie for a few days – the same town Alan (hubby) and I spent our honeymoon many, many years earlier.

    This particular day, Alan and our two (then) teenage offspring wanted to go to
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    the beach. I had a terrible feeling of foreboding, impending disaster. We went, much to my dismay, and Alan was dragged out into the sea by a King Tide and nearly drowned. I’m waiting for the right anthology to come along.

    The trick here is to write these things down. Put them in a box, a binder, or even a card file. You don’t even need to elabo
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    ate. The basics will probably be enough to jog your memory. We are all a wealth of information – memories are a wonderful asset. In addition to providing us with scores of material, they provide emotional links as well. It is the emotional tie that often wins the editor over, so don’t dwell just on the facts. Elaborate, and bare your soul.

    You ca
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    n use a similar technique for short stories, but you will also need to fabricate information. For example, I went to my local supermarket for a few grocery items. When I arrived, the police were there taking statements. One of the cashiers explained (to me) that they had been robbed. The thief made his getaway by literally running through the sto
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    e, then taking a flying leap over some shopping trolleys parked near the registers.

    Humour writing is one of my strong points – in fact, the Kelly and Tony Mystery Series are all comedy/crime stories. That particular story tickled my funny bone. You guessed right; I turned it into a short story. As Kelly (my main protagonist) has a fetish for tig
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    ht butts (male of course!) I worked that into the story. The result is a very funny story that I’m considering using in my Kelly and Tony novel (as yet un-named).

    My unsolicited advice is to really look around you, open your eyes, see your surroundings. Don’t just walk down the street, ride your bike or do your shopping – instead, witness a story


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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